LY2922470 New
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| CAS No. | 1423018-12-5 | Cat. No. | BCP24962 |
| Name | LY2922470 | ||
| Synonyms | LY-2922470; LY 2922470; | ||
| SMILES | CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=C(S2)CN3CCCC4=C3C(=CC=C4)OC | ||
| Chemical Name | |||
| Formula | C28H29NO4S | M. Wt | 475.6 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | LY2922470 is a Potent and Selective GPR40 Agonist for the Treatment of Type 2 Diabetes Mellitus. LY2922470 demonstrated potent, efficacious and durable dose dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion during preclinical testing. The G protein-coupled receptor 40 (GPR40) also known as Free Fatty Acid Receptor 1 (FFAR1) is highly expressed in pancreatic, islet beta-cells and responds to endogenous fatty acids resulting in amplification of insulin secretion only in the presence of elevated glucose levels. | ||
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