SP2509
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1423715-09-6 | Cat. No. | BCP13042 |
| Name | SP2509 | ||
| Synonyms | SP-2509;SP 2509; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C19H20ClN3O5S | M. Wt | 437.9 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SP-2509 is a novel histone demethylase LSD1 inhibitor, which showed high actitivity on human AML cells. Treatment with the novel LSD1 antagonist SP2509 attenuated the binding of LSD1 with the corepressor CoREST, increased the permissive H3K4Me3 mark on the target gene promoters, and increased the levels of p21, p27 and CCAAT/enhancer binding protein α in cultured AML cells. In addition, SP2509 treatment or LSD1 shRNA inhibited the colony growth of AML cells. | ||
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