VLX1570
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1431280-51-1 | Cat. No. | BCP18900 |
| Name | VLX1570 | ||
| Synonyms | VLX-1570;VLX 1570; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C23H17F2N3O6 | M. Wt | 469.39 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | VLX1570 is an inhibitor of the 19S proteasome-specific deubiquitylating enzymes (DUBs) USP14 and UCHL5, with apoptosis-inducing and antineoplastic activities. Upon administration, VLX1570 specifically binds to both USP14 and UCHL5, thereby blocking their deubiquitylating activity. This blocks the ubiquitin proteasome degradation pathway, prevents the degradation of defective proteins, and leads to an accumulation of poly-ubiquitylated proteins. This induces the unfolded protein response (UPR) and results in both the induction of tumor cell apoptosis and the inhibition of tumor cell growth. | ||
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