Triapine
Data Sheet
For research use only. Not for human use.
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| CAS No. | 143621-35-6 | Cat. No. | BCP14673 |
| Name | Triapine | ||
| Synonyms | 3-AP;3AP;3 AP;PAN-811;PAN 811;PAN811;OCX191;OCX 191;OCX-191;NSC663249;NSC 663249;NSC-663249; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C7H9N5S | M. Wt | 195.248 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | 3-AP and 3-AP-Me activated the cellular stress kinases c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases, and inhibition of JNK activity antagonized the cytotoxic effect of both compounds. 3-AP and 3-AP-Me induce apoptosis via ER stress. Triapine abolishes olaparib-induced BRCA1 and Rad51 foci, and disrupts the BRCA1 interaction with the Mre11-Rad50-Nbs1 (MRN) complex in BRCA1 wild-type EOC cells. triapine inhibits cyclin-dependent kinase (CDK) activity and blocks olaparib-induced CtIP phosphorylation through Chk1 activation. triapine abrogates etoposide-induced CtIP phosphorylation and DSB resection as evidenced by marked attenuation of RPA32 phosphorylation. | ||
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