BRD73954
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1440209-96-0 | Cat. No. | BCP12818 |
| Name | BRD73954 | ||
| Synonyms | BRD-73954;BRD 73954; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C16H16N2O3 | M. Wt | 284.31 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BRD73954 is the first small molecule histone deacetylase (HDAC) inhibitor, capable of potently and selectively inhibiting both HDAC6 and HDAC8, despite the fact that these isoforms belong to distinct phylogenetic classes within the HDAC family of enzymes. Our data demonstrate that meta substituents of phenyl hydroxamic acids are readily accommodated upon binding to HDAC6 and, furthermore, are necessary for the potent inhibition of HDAC8. At 10 ?M, BRD73954 treatment results in a robust increase in acetylation of α-tubulin, a known HDAC6 substrate, but not histone H3, a substrate for HDAC1, 2, and 3, in HeLa cells. | ||
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