Pixantrone

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP05981CAS No. ：144510-96-3Purity：98%

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CAS No.	144510-96-3	Cat. No.	BCP05981
Name	Pixantrone
Synonyms	Pixuvri;BBR-2778;BBR2778;BBR 2778;
SMILES
Chemical Name
Formula	C17H19N5O2	M. Wt	325.37
Purity	98%	Storage	Store at 4-8°C
Description	Pixantrone is an experimental antineoplastic (anti-cancer) drug, an analogue of mitoxantrone with fewer toxic effects on cardiac tissue, It acts as a topoisomerase II poison and intercalating agent. Pixantrone may be useful in patients pretreated with anthracyclines. An in vitro crosslinking assay demonstrated that Pixantrone is efficiently activated by formaldehyde to generate covalent drug-DNA adducts capable of stabilizing double-stranded DNA in denaturing conditions. Pixantrone-DNA adduct formation is both concentration and time dependent and the reaction exhibits an absolute requirement for formaldehyde. Pixantrone exhibited a 10- to 100-fold greater propensity to generate adducts at equimolar formaldehyde and drug concentrations. Pixantrone-DNA adducts are thermally and temporally labile, yet they exhibit a greater thermal midpoint temperature and an extended half-life at 37 degrees C when compared to mitoxantrone-DNA adducts.