Olmesartan
Data Sheet
For research use only. Not for human use.
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| CAS No. | 144689-24-7 | Cat. No. | BCP12007 |
| Name | Olmesartan | ||
| Synonyms | RNH 6270;RNH-6270;RNH6270;CS 088;CS-088;CS088; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C24H26N6O3 | M. Wt | 446.5 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Olmesartan medoxomil is a prodrug, that is hydrolyzed to olmesartan during absorption from the gastrointestinal tract. It works by blocking the binding of angiotensin II to the AT1 receptors in vascular muscle; it is therefore independent of angiotensin II synthesis pathways, unlike ACE inhibitors. By blocking the binding rather than the synthesis of angiotensin II, olmesartan inhibits the negative regulatory feedback on renin secretion. As a result of this blockage, olmesartan reduces vasoconstriction and the secretion of aldosterone. This lowers blood pressure by producing vasodilation, and decreasing peripheral resistance. | ||
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