Senexin B
Data Sheet
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| CAS No. | 1449228-40-3 | Cat. No. | BCP20861 |
| Name | Senexin B | ||
| Synonyms | Senexin-B; | ||
| SMILES | O=C(C1=CC2=CC=C(CCNC3=C4C(C=CC(C#N)=C4)=NC=N3)C=C2C=C1)N5CCN(C)CC5 | ||
| Chemical Name | |||
| Formula | C27H26N6O | M. Wt | 450.55 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Senexin B is a potent and selective CDK8/19 inhibitor. Senexin B inhibits CDK8/19 in low nanomolar range in vitro and in vivo as an ATP pocket binder, with very high target selectivity as indicated by kinome profiling. It is highly water-soluble, bioavailable, and produces no limiting toxicity upon prolonged administration in mice, at doses that yield plasma concentrations exceeding cellular IC50 by 2-3 orders of magnitude. CDK8/19 inhibition produces chemopotentiating, chemopreventive and anti-metastatic effects in different types of cancer, inhibiting tumor progression by acting both at the tumor cells (the “seed”) and the tumor microenvironment (the “soil”) of cancers. | ||
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