DDR1-IN-1
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1449685-96-4 | Cat. No. | BCP10994 |
| Name | DDR1-IN-1 | ||
| Synonyms | DDR1-IN 1; DDR1-IN1; | ||
| SMILES | O=C(NC1=CC=C(C)C(OC2=CC3=C(NC(C3)=O)C=C2)=C1)C4=CC=C(CN5CCN(CC)CC5)C(C(F)(F)F)=C4 | ||
| Chemical Name | |||
| Formula | C30H31F3N4O3 | M. Wt | 552.59 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | DDR1-IN-1 is a potent and selective DDR1 inhibitor with IC50 of 105 nM, about 3-fold selectivity over DDR2. DDR1-IN-1 binds to DDR1 in the 'DFG-out' conformation and inhibits DDR1 autophosphorylation in cells at submicromolar concentrations with good selectivity as assessed against a panel of 451 kinases measured. DDR1-IN-1 provides a useful pharmacological probe for DDR1-dependent signal transduction. The DDR1 receptor tyrosine kinase is activated by matrix collagens and has been implicated in numerous cellular functions such as proliferation, differentiation, adhesion, migration, and invasion. | ||
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