Paritaprevir dihydrate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1456607-71-8 | Cat. No. | BCP20006 |
| Name | Paritaprevir dihydrate | ||
| Synonyms | ATB450 dihydrate; ABT-450 dihydrate; ABT 450 dihydrate; | ||
| SMILES | CC1=NC=C(N=C1)C(=O)NC2CCCCCC=CC3CC3(NC(=O)C4CC(CN4C2=O)OC5=NC6=CC=CC=C6C7=CC=CC=C75)C(=O)NS(=O)(=O)C8CC8.O.O | ||
| Chemical Name | |||
| Formula | C40H43N7O7S.2(H2O) | M. Wt | 801.91 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Paritaprevir, also known as ABT-450 or Veruprevir, is an acylsulfonamide inhibitor of the NS3-4A serine protease manufactured by Abbott Laboratories that shows promising results as a treatment of hepatitis C. When given in combination with ritonavir and ribavirin for 12 weeks, the rate of sustained virologic response at 24 weeks after treatment has been estimated to be 95% for those with hepatitis C virus genotype 1. Resistance to treatment with paritaprevir is uncommon, because it targets the binding site, but has been seen to arise due to mutations at positions 155 and 168 in NS3. | ||
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