JTV-519 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 145903-06-6 | Cat. No. | BCP17477 |
| Name | JTV-519 | ||
| Synonyms | JTV519；JTV 519；K201;K-201;K 201; | ||
| SMILES | COC1=CC2=C(C=C1)SCCN(C2)C(=O)CCN3CCC(CC3)CC4=CC=CC=C4 | ||
| Chemical Name | |||
| Formula | C25H32N2O2S | M. Wt | 424.6 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | JTV-519 (K201) is a 1,4-benzothiazepine derivative that interacts with many cellular targets. It has many structural similarities to diltiazem, a Ca2+ channel blocker used for treatment of hypertension, angina pectoris and some types of arrhythmias.JTV-519 acts in the sarcoplasmic reticulum (SR) of cardiac myocytes by binding to and stabilizing the ryanodine receptor (RyR2) in its closed state. It can be used in the treatment of cardiac arrhythmias, heart failure, catecholaminergic polymorphic ventricular tachycardia (CPVT) and store overload-induced Ca2+ release (SOICR) | ||
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