Ziprasidone

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02195CAS No. ：146939-27-7Purity：98%

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CAS No.	146939-27-7	Cat. No.	BCP02195
Name	Ziprasidone
Synonyms	CP-88059;CP 88059;CP88059;Geodon;
SMILES
Chemical Name
Formula	C21H21ClN4OS	M. Wt	412.94
Purity	98%	Storage	Store at 4-8°C
Description	Ziprasidone possesses an in vitro 5-HT2A/dopamine D2 receptor affinity ratio higher than any clinically available antipsychotic agent. In vivo, ziprasidone antagonizes 5-HT2A receptor-induced head twitch with 6-fold higher potency than for blockade of d-amphetamine-induced hyperactivity, a measure of central dopamine D2 receptor antagonism. Ziprasidone also has high affinity for the 5-HT1A, 5-HT1D and 5-HT2C receptor subtypes, which may further enhance its therapeutic potential. Ziprasidone sulfoxide and sulfone were the major metabolites in human serum. The affinities of the sulfoxide and sulfone metabolites for 5-HT2 and D2 receptors are low with respect to ziprasidone, and are thus unlikely to contribute to its antipsychotic effects . Ziprasidone was associated with significant differential adverse effects relative to placebo in BPM, BPD, and schizophrenia with no significant difference in weight gain in all 3 groups. Self-reported somnolence was increased across the 3 conditions. S