Asciminib

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP28932CAS No. ：1492952-76-7Purity：98%

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CAS No.	1492952-76-7	Cat. No.	BCP28932
Name	Asciminib
Synonyms	ABL001；ABL-001; ABL 001;
SMILES
Chemical Name
Formula	C20H18ClF2N5O3	M. Wt	449.84
Purity	98%	Storage	Store at 4-8°C
Description	Asciminib, also known as ABL001, is a potent allosteric inhibitor of BCR-ABL. ABL001 prevents emergence of resistant disease when administered in combination with nilotinib in an in vivo murine model of chronic myeloid leukemia. Cell proliferation studies demonstrate that ABL001 selectively inhibited the growth of CML and Ph+ ALL cells with potencies ranging from 1-10nM range. ABL001 was tested for activity against clinically observed mutations and found to be active in the low nM range. In the KCL-22 mouse xenograft model, ABL001 displayed potent anti-tumor activity with complete tumor regression observed and a clear dose-dependent correlation with pSTAT5 inhibition.