Azimilide

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP16964CAS No. ：149908-53-2Purity：98%

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CAS No.	149908-53-2	Cat. No.	BCP16964
Name	Azimilide
Synonyms	NE-10064;NE 10064;NE10064;
SMILES
Chemical Name
Formula	C23H28ClN5O3	M. Wt	457.95
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: Azimilide blocked HERG channels at 0.1 and 1 Hz with IC50s of 1.4 microM and 5.2 microM respectively. Azimilide blockade of HERG channels expressed in Xenopus oocytes and I(Kr) in mouse AT-1 cells was decreased under conditions of high [K+]e, whereas block of slowly activating I(Ks) channels was not affected by changes in [K+]e. Azimilide suppressed the following currents (Kd in parenthesis): IKr (< 1 microM at -20 mV), IKs (1.8 microM at +30 mV), L-type Ca current (17.8 microM at +10 mV), and Na current (19 microM at -40 mV). Azimilide was a weak blocker of the transient outward and inward rectifier currents (Kd > or = 50 microM at +50 and -140 mV, respectively). Azimilide blocked IKr, IKs, and INa in a use-dependent manner. Furthermore, azimilide reduced a slowly inactivating component of Na current that might be important for maintaining the action potential plateau in canine ventricular myocytes. In guinea pig ventricular myocytes, NE-10064 (0.3-3 microM) significantly pr