MS049
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1502816-23-0 | Cat. No. | BCP20715 |
| Name | MS049 | ||
| Synonyms | MS-049; MS 049; | ||
| SMILES | CNCCN1CCC(OCC2=CC=CC=C2)CC1 | ||
| Chemical Name | |||
| Formula | C15H24N2O | M. Wt | 248.37 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM respectively. target: PRMT4, PRMT6; IC 50: 34 nM (PRMT4 ), 43 nM (PRMT6 ); In vitro: MS 049 reduces the H3R2me2a mark in HEK293 cells in a concentration dependent manner. MS 049 treatment (72 h exposure) inhibits endogenous PRMT4 methyltransferase activity in a concentration dependent manner resulting in reduced levels of cellular asymmetric arginine dimethylation of Med12 (Med12-Rme2a, IC50 = 1.4 ± 0.1 μM (n = 3)) in HEK293 cells. | ||
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