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SAR405 Chemical Structure

SAR405

Data Sheet For research use only. Not for human use.
Cat. No. :BCP24772CAS No. :1523406-39-4Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1523406-39-4 Cat. No. BCP24772
Name SAR405
Synonyms SAR 405; SAR-405;
SMILES
Chemical Name
Formula C19H21ClF3N5O2 M. Wt 443.85
Purity 98% Storage Store at 4-8°C
Description SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405 with everolimus results in a significant synergy on the reduction of cell proliferation using renal tumor cells.
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