Imatinib

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01542CAS No. ：152459-95-5Purity：98%

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CAS No.	152459-95-5	Cat. No.	BCP01542
Name	Imatinib
Synonyms	STI571;Glivec;STI-571;STI 571;STI571;
SMILES
Chemical Name
Formula	C29H31N7O	M. Wt	493.6
Purity	98%	Storage	Store at 4-8°C
Description	In vitro assays for inhibition of a panel of tyrosine and serine/threonine protein kinases show that Imatinib inhibits the v-Abl tyrosine kinase and PDGFR potently with an IC50 of 0.6 and 0.1 μM, respectively.Imatinib inhibits the SLF-dependent activation of wild-type c-kit kinase activity with a IC50 for these effects of approximately 0.1 μM, which is similar to the concentration required for inhibition of PDGFR. Imatinib exhibits growth-inhibitory activity on the human bronchial carcinoid cell line NCI-H727 and the human pancreatic carcinoid cell line BON-1 with an IC50 of 32.4 and 32.8 μM, respectively. A recent study shows that Imatinib has the potential to exert its antileukemia effects in chronic myelogenous leukemia by down-regulating hERG1 K(+) channels, which are highly expressed in leukemia cells and appear of exceptional importance in favoring leukemogenesis.