A-366
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1527503-11-2 | Cat. No. | BCP17827 |
| Name | A-366 | ||
| Synonyms | A 366;A366; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C19H27N3O2 | M. Wt | 329.44 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | A-366 is a potent inhibitor of G9a/GLP with IC50 3 nM and > 100-fold selectivity over other methyltransferases and other non-epigenetic targets. A-366 has been shown to inhibit H3K9 methylation in cells with an IC50 of 100 nM and exhibits minimal cellular toxicity compared with previous quinazoline-based probes. A-366 selectively inhibits G9a and the closely related GLP (EHMT1), but not other histone methyltransferases. A-366 has significantly less cytotoxic effects on the growth of tumor cell lines compared to other known G9a/GLP small molecule inhibitors despite equivalent cellular activity on methylation of H3K9me2. | ||
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