Umbralisib New
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| CAS No. | 1532533-67-7 | Cat. No. | BCP24686 |
| Name | Umbralisib | ||
| Synonyms | TGR1202; TGR 1202; TGR-1202; RP5264; RP 5264; RP-5264; | ||
| SMILES | CC(C)OC1=C(C=C(C=C1)C2=NN(C3=NC=NC(=C23)N)C(C)C4=C(C(=O)C5=C(O4)C=CC(=C5)F)C6=CC(=CC=C6)F)F | ||
| Chemical Name | |||
| Formula | C31H24F3N5O3 | M. Wt | 571.55 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Umbralisib, also known as TGR1202 and RP5264 , is a highly specific, orally available, PI3K delta inhibitor, targeting the delta isoform with nanomolar potency and several fold selectivity over the alpha, beta, and gamma isoforms of PI3K. Inhibition of PI3K delta signaling with TGR-1202 has demonstrated robust activity in numerous pre-clinical models and primary cells from patients with hematologic malignancies. | ||
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