Cilomilast

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02394CAS No. ：153259-65-5Purity：98%

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CAS No.	153259-65-5	Cat. No.	BCP02394
Name	Cilomilast
Synonyms	Ariflo;SB-207499;SB 207499;SB207499;
SMILES
Chemical Name
Formula	C20H25NO4	M. Wt	343.42
Purity	98%	Storage	Store at 4-8°C
Description	Cilomilast produces a concentration-dependent increase in cAMP content in U937 cells. Cilomilast produces a concentration-dependent increase in cAMP content in U937 cells. In isolated human monocytes, Cilomilast and (R)-rolipram are equipotent at suppressing LPS-induced TNF-α formation with -log (IC50) of 7.0 and 7.2, respectively. Both Cilomilast and (R)-rolipram produces a modest prevention of fMLP-induced degranulation of human neutrophils. Cilomilast and (R)-rolipram are equipotent at suppressing neutrophil activation with -log (IC50) of 7.1 and 6.4, respectively. Cilomilast significantly decreases the expression of TNF-α in the cornea and IL-1α, IL-1β, and TNF-α in the conjunctivaas compared to vehicle control. Cilomilast treatment markedly decreases the presence of CD11b+ antigen-presenting cells in the central and peripheral cornea, and leads to decreased conjunctival expression of cytokines IL-6, IL-23, and IL-17. Moreover, Cilomilast decreases the expression of IL-17 and IL-23