Fexofenadine HCl
Data Sheet
For research use only. Not for human use.
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| CAS No. | 153439-40-8 | Cat. No. | BCP02191 |
| Name | Fexofenadine HCl | ||
| Synonyms | CHEM-1861;CHEM 1861;CHEM1861; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C32H40ClNO4 | M. Wt | 538.12 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Fexofenadine exhibits a potent and concentration-dependent anti-anaphylactic activity with an IC50 value of 95.5nM. Fexofenadine shows only a weak competitive antagonist behaviour for the 5-HT2A receptorsfrom rat caudal artery with pA2 of 5.2. [1] All four P-gp inhibitors has a strong, concentration-dependent effect on the Papp of fexofenadine in both directions in the Caco-2 cell model. The IC50 of verapamil is 8.44 mM on the P-gp-mediated secretion of Fexofenadine.Fexofenadine causes a significant increase in the QT and Tp-e intervals and receives a significant TdP score at doses greater than 100 fold its free TPC in the rabbit left ventricular wedge preparation. | ||
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