Marimastat

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP10998CAS No. ：154039-60-8Purity：98%

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CAS No.	154039-60-8	Cat. No.	BCP10998
Name	Marimastat
Synonyms	BB 2516;BB2516;BB-2516;GI 5712;GI5712;GI-5712;KB-R 8898;TA 2516; TA2516; TA-2516;
SMILES	CC(C)CC(C(C(=O)NO)O)C(=O)NC(C(=O)NC)C(C)(C)C
Chemical Name
Formula	C15H29N3O5	M. Wt	331.41
Purity	98%	Storage	Store at 4-8°C
Description	Marimastat, aslo known as BB-2516 and TA-2516, is an orally-active synthetic hydroxamate and inhibitor of matrix metalloproteinases with potential antineoplastic activity. Marimastat covalently binds to the zinc(II) ion in the active site of matrix metalloproteinases (MMPs), thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent may also inhibit tumor necrosis factor-alpha converting enzyme (TACE), an enzyme involved in tumor necrosis factor alpha (TNF-alpha) production that may play a role in some malignancies as well as in the development of arthritis and sepsis.