Rosiglitazone maleate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 155141-29-0 | Cat. No. | BCP05335 |
| Name | Rosiglitazone maleate | ||
| Synonyms | BRL 49653C;Avandia; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C22H23N3O7S | M. Wt | 473.5 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | in vitro: In competition experiments, rosiglitazone (BRL-49653), a potent antihyperglycemic agent, binds with high affinity to sites in intact adipocytes (IC50 = 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively). Rosiglitazone could induce AMP-activated protein kinase (AMPK) phosphorylation and reduce p70S6 kinase phosphorylation. Inhibition of AMPK impaired autophagy activation and enhanced palmitate-induced apoptosis during rosiglitazone treatment. Rosiglitazone-treated beta-cells were more resistant to palmitate-induced apoptosis. The conversion of LC3-I to LC3-II and accumulated autophagosomes were found to be upregulated in rosiglitazone-treated cells [2]. in vivo: In LFD mice with AP, Rosiglitazone(RGZ) significantly worsened the degree of intrapancreatic acinar and fat necrosis as well as visceral fat saponification, without affecting other parameters of disease severity or inflammation. Induction of AP lead to major suppression of adiponectin levels at Day 7 in | ||
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