BAY-1217389
Data Sheet
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| CAS No. | 1554458-53-5 | Cat. No. | BCP17401 |
| Name | BAY-1217389 | ||
| Synonyms | BAY1217389; | ||
| SMILES | O=C(NC1CC1)C2=CC=C(C3=CN=C4C(NCCC(F)(F)F)=CC(OC5=CC=C(OC)C(F)=C5F)=NN43)C=C2C | ||
| Chemical Name | |||
| Formula | C27H24F5N5O3 | M. Wt | 561.5 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BAY1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1, TTK), with potential antineoplastic activity. Upon administration, the Mps1 inhibitor BAY 1217389 selectively binds to and inhibits the activity of Mps1. This inactivates the spindle assembly checkpoint (SAC), accelerates mitosis, causes chromosomal misalignment and missegregation, and mitotic checkpoint complex destabilization. This induces cell death in Mps1-overexpressing cancer cells. | ||
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