Avitinib

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP16381CAS No. ：1557267-42-1Purity：98%

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CAS No.	1557267-42-1	Cat. No.	BCP16381
Name	Avitinib
Synonyms	AC0010; AC-0010; AC 0010;
SMILES
Chemical Name
Formula	C26H26FN7O2	M. Wt	487.53
Purity	98%	Storage	Store at 4-8°C
Description	Avitinib, also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity. Upon oral administration, avitinib covalently binds to and inhibits the activity of mutant forms of EGFR, including the drug-resistant T790M EGFR mutant, which prevents signaling mediated by mutant forms of EGFR. This may both induce cell death and inhibit tumor growth in EGFR-mutated tumor cells. EGFR, a receptor tyrosine kinase that is mutated in a variety of cancers, plays a key role in tumor cell proliferation and tumor vascularization. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced when compared to non-selective EGFR inhibitors, which also inhibit wild-type EGFR.