SGC 0946
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1561178-17-3 | Cat. No. | BCP06832 |
| Name | SGC 0946 | ||
| Synonyms | SGC0946; SGC-0946; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C28H40BrN7O4 | M. Wt | 618.57 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Potent DOT1L methyltransferase inhibitor (KD = 0.06 nM, IC50 = 0.3 nM in a radioactive assay); blocks H3K79 methylation in A431 cells and MCF10A cells (IC50 values are 2.65 and 8.8 nM respectively). Inactive at 12 histone methyltransferases and DNMT1. Selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia; lowers levels of MLL target genes HOXA9 and Meis1. | ||
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