Perifosine
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CAS No. | 157716-52-4 | Cat. No. | BCP00245 |
Name | Perifosine | ||
Synonyms | KRX-0401;NSC 639966;D-21266;KRX 0401;KRX0401;D21266;D 21266; | ||
SMILES | |||
Chemical Name | |||
Formula | C25H52NO4P | M. Wt | 461.66 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Perifosine develops anti-proliferative properties with IC50 of 0.6-8.9 μM in immortalized keratinocytes (HaCaT), and head and neck squamous carcinoma cells. [1] Perifosine strongly reduces phosphorylation levels of Akt and extracellular signal-regulated kinase (Erk) 1/2, induces cell cycle arrest in G1 and G2, and causes dose-dependent growth inhibition of mouse glial progenitors. Perifosine (10 μM) completely inhibits the phosphorylation of Akt in MM.1S cells. A recent study demonstrates Per |
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