Everolimus

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01806CAS No. ：159351-69-6Purity：98%

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CAS No.	159351-69-6	Cat. No.	BCP01806
Name	Everolimus
Synonyms	RAD001;SDZ-RAD;Certican; RAD 001; RAD-001;
SMILES
Chemical Name
Formula	C53H83NO14	M. Wt	958.25
Purity	98%	Storage	Store at 4-8°C
Description	Everolimus exhibits the immunosuppressive activity which is comparable to that of rapamycin. Everolimus competes with immobilized FK 506 for binding to biotinylated FKBP12 and shows the inhibitory effect on a two-way MLR performed with spleen cells from BALB/c and CBA mice with IC50 of 0.12-1.8 nM. Everolimus also shows antiangiogenic/vascular effects in VEGF-induced HUVEC proliferation with IC50 of 0.12 nM and bFGF-induced HUVEC proliferation with IC50 of 0.8 nM, respectively. A recent study shows that Everolimus shows a dose-dependent inhibitory effects on both the total cells and the stem cells from the BT474 cell line and the primary breast cancer cells with IC50 of 156 nM in total cells of primary breast cancer cells and 71 nM in total cells of BT474 cells. In addition, combination treatment with Everolimus and trastuzumab produces the significantly increased inhibition on the growth of cancer stem cells with the inhibition rate increased by more than 50 %.