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THZ1 Chemical Structure

THZ1

Data Sheet For research use only. Not for human use.
Cat. No. :BCP10167CAS No. :1604810-83-4Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1604810-83-4 Cat. No. BCP10167
Name THZ1
Synonyms THZ-1;THZ 1;CDK7 inhibitor;
SMILES
Chemical Name
Formula C31H28ClN7O2 M. Wt 566.05
Purity 98% Storage Store at 4-8°C
Description THZ1 is a selective CDK7 inhibitor that preferentially diminishes transcription in cancer cells. THZ1 has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. Cancer cell-line profiling indicates that a subset of cancer cell lines, including human T-cell acute lymphoblastic leukaemia (T-ALL), have exceptional sensitivity to THZ1. Cyclin-dependent kinases (CDKs) are involved in temporal control of the cell cycle and transcription and play central roles in cancer development and metastasis.
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