THZ1
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1604810-83-4 | Cat. No. | BCP10167 |
| Name | THZ1 | ||
| Synonyms | THZ-1;THZ 1;CDK7 inhibitor; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C31H28ClN7O2 | M. Wt | 566.05 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | THZ1 is a selective CDK7 inhibitor that preferentially diminishes transcription in cancer cells. THZ1 has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. Cancer cell-line profiling indicates that a subset of cancer cell lines, including human T-cell acute lymphoblastic leukaemia (T-ALL), have exceptional sensitivity to THZ1. Cyclin-dependent kinases (CDKs) are involved in temporal control of the cell cycle and transcription and play central roles in cancer development and metastasis. | ||
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