ARN-3236

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP25158CAS No. ：1613710-01-2Purity：98%

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CAS No.	1613710-01-2	Cat. No.	BCP25158
Name	ARN-3236
Synonyms	ARN 3236; ARN3236;
SMILES
Chemical Name
Formula	C19H16N2O2S	M. Wt	336.41
Purity	98%	Storage	Store at 4-8°C
Description	ARN-3236 is potent, orally active and selective SIK2 inhibitor. ARN-3236 inhibited the growth of 10 ovarian cancer cell lines at an IC50 of 0.8 to 2.6 μmol/L. ARN-3236 enhanced sensitivity to paclitaxel in 8 of 10 cell lines, as well as in SKOv3ip (P = 0.028) and OVCAR8 xenografts. ARN-3236 uncoupled the centrosome from the nucleus in interphase, blocked centrosome separation in mitosis, caused prometaphase arrest, and induced apoptotic cell death and tetraploidy. ARN-3236 also inhibited AKT phosphorylation and attenuated survivin expression. ARN-3236 is the first orally available inhibitor of SIK2 to be evaluated against ovarian cancer in preclinical models and shows promise in inhibiting ovarian cancer growth and enhancing paclitaxel chemosensitivity.