GSK591 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1616391-87-7 | Cat. No. | BCP17092 |
| Name | GSK591 | ||
| Synonyms | GSK-591;GSK 591; EPZ015866; EPZ-015866; EPZ 015866; GSK 3203591; GSK-3203591; GSK3203591; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C22H28N4O2 | M. Wt | 380.49 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GSK591 is a chemical probe for PRMT5. In an in vitro biochemical assay, GSK591 potently inhibits the PRMT5/MEP50 complex from methylating (histone) H4 with IC50 = 11 nM. In Z-138 cells, GSK591 inhibits the symmetric arginine methylation of SmD3 with EC50 = 56 nM. Further, GSK591 is selective for PRMT5 (up to 50 micromolar) relative to a panel of methyltransferases. | ||
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