Rofecoxib
Data Sheet
For research use only. Not for human use.
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| CAS No. | 162011-90-7 | Cat. No. | BCP03619 |
| Name | Rofecoxib | ||
| Synonyms | MK 966;Vioxx;MK966;MK-966; MK0966; MK0966; MK 0966; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C17H14O4S | M. Wt | 314.36 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Rofecoxib is a synthetic, nonsteroidal derivative of phenyl-furanone with antiinflammatory, antipyretic and analgesic properties and potential antineoplastic properties. Rofecoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. COX-related metabolic pathways may represent key regulators of cell proliferation and neo-angiogenesis. Some epithelial tumor cell types overexpress pro-angiogenic COX-2. Rofecoxib was used as an anti-inflammatory analgesic which has now been withdrawn from the market because of its association with cardiovascular problems. | ||
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