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AZD0914 Chemical Structure

AZD0914

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP19546CAS No. ：1620458-09-4Purity：97%
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  • Chemical Properties&Biological Activity
CAS No. 1620458-09-4 Cat. No. BCP19546
Name AZD0914
Synonyms ETX0914; ETX-0914; ETX 0914;Zoliflodacin;AZD-0914;AZD 0914;
SMILES
Chemical Name
Formula C22H22FN5O7 M. Wt 487.44
Purity 97% Storage Store at 4-8°C
Description AZD0914, also known as Zoliflodacin and ETX0914, is a new spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor with potent in vitro antibacterial activity against key Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, and Streptococcus agalactiae), fastidious Gram-negative (Haemophilus influenzae and Neisseria gonorrhoeae), atypical (Legionella pneumophila), and anaerobic (Clostridium difficile) bacterial species, including isolates with known resistance to fluoroquinolones. AZD0914 works via inhibition of DNA biosynthesis and accumulation of double-strand cleavages.
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