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AZD8186 Chemical Structure

AZD8186

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP28809CAS No. ：1627494-13-6Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1627494-13-6 Cat. No. BCP28809
Name AZD8186
Synonyms AZD 8186; AZD-8186;
SMILES
Chemical Name
Formula C24H25F2N3O4 M. Wt 457.47
Purity 98% Storage Store at 4-8°C
Description AZD8186 is and inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity. Upon administration, PI3Kbeta inhibitor AZD8186 selectively inhibits the activity of PI3Kbeta in the PI3K/Akt/mTOR signaling pathway, which may result in a decrease of tumor cell proliferation. It also induces cell death in PI3K-expressing cancer cells. By specifically targeting class I PI3K beta, this agent may be more efficacious and less toxic than pan PI3K inhibitors. PI3K-mediated signaling is often dysregulated in cancer cells and contributes to increased tumor cell growth, survival, and tumor resistance to a variety of antineoplastic agents. AZD8186 is currently under Phase I clinical trials.
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