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CPI-455 Chemical Structure

CPI-455

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP20722CAS No. ：1628208-23-0Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1628208-23-0 Cat. No. BCP20722
Name CPI-455
Synonyms CPI 455;CPI455;
SMILES
Chemical Name
Formula C16H15ClN4O M. Wt 314.77
Purity 98% Storage Store at 4-8°C
Description CPI-455 is an inhibitor of the lysine demethylase 5 family (KDM5A-D). CPI-455 binds to the demethylase active site and selectively inhibits KDM5A-D (IC50s = 2-10 nM) over KDM2-4, 6, and 7 family members (IC50s = 1 to >25 μM). It increases histone H3K4me2/3 methylation in vitro and decreases the number of drug-tolerant cells in PC9 non-small cell lung, M14 melanoma, and SKBR3 breast cancer cell populations. CPI-455 also reduces growth of glioblastoma cells resistant to temozolomide in a dose-dependent manner.
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H-NMR
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