MI-136
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1628316-74-4 | Cat. No. | BCP20862 |
| Name | MI-136 | ||
| Synonyms | MI 136; MI136; | ||
| SMILES | FC(F)(F)CC(S1)=CC2=C1N=CN=C2NC3CCN(CC4=CC=C(NC(C#N)=C5)C5=C4)CC3 | ||
| Chemical Name | |||
| Formula | C23H21F3N6S | M. Wt | 470.52 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | MI-136 is an inhibitor of the menin-MLL interaction (IC50 = 31 nM; Kd = 23.6 nM).1,2 By blocking MLL recruitment predominantly at the level of the menin-MLL interaction, it can inhibit androgen receptor (AR)-mediated transcription. At 40 mg/kg, MI-136 has been shown to block AR signaling, inhibiting the growth of castration-resistant tumors in mice. | ||
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