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FIIN-3 Chemical Structure

FIIN-3

Data Sheet For research use only. Not for human use.
Cat. No. :BCP28774CAS No. :1637735-84-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1637735-84-2 Cat. No. BCP28774
Name FIIN-3
Synonyms FIIN3; FIIN 3;
SMILES
Chemical Name
Formula C34H36Cl2N8O4 M. Wt 691.61
Purity 98% Storage Store at 4-8°C
Description FIIN-3 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-3 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. FIIN-3 has the unprecedented ability to inhibit both the EGF receptor (EGFR) and FGFR covalently by targeting two distinct cysteine residues. FIIN-3 bound with FGFR4 V550L and EGFR L858R.
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