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ETC-159 Chemical Structure

ETC-159

Data Sheet For research use only. Not for human use.
Cat. No. :BCP20688CAS No. :1638250-96-0Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1638250-96-0 Cat. No. BCP20688
Name ETC-159
Synonyms ETC159; ETC 159; ETC-1922159; ETC 1922159; ETC1922159;
SMILES
Chemical Name
Formula C19H17N7O3 M. Wt 391.38
Purity 98% Storage Store at 4-8°C
Description ETC-159, also known as ETC-1922159, is a potent, selective and orally available PORCN inhibitor. ETC-159 blocks the secretion and activity of all Wnts. ETC-159 is remarkably effective in treating RSPO-translocation bearing colorectal cancer (CRC) patient-derived xenografts. Inhibition of Wnt signaling by PORCN inhibition holds promise as differentiation therapy in genetically defined human cancers. Enhanced sensitivity to Wnts is an emerging hallmark of a subset of cancers, defined in part by mutations regulating the abundance of their receptors.
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