ETC-159
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CAS No. | 1638250-96-0 | Cat. No. | BCP20688 |
Name | ETC-159 | ||
Synonyms | ETC159; ETC 159; ETC-1922159; ETC 1922159; ETC1922159; | ||
SMILES | |||
Chemical Name | |||
Formula | C19H17N7O3 | M. Wt | 391.38 |
Purity | 98% | Storage | Store at 4-8°C |
Description | ETC-159, also known as ETC-1922159, is a potent, selective and orally available PORCN inhibitor. ETC-159 blocks the secretion and activity of all Wnts. ETC-159 is remarkably effective in treating RSPO-translocation bearing colorectal cancer (CRC) patient-derived xenografts. Inhibition of Wnt signaling by PORCN inhibition holds promise as differentiation therapy in genetically defined human cancers. Enhanced sensitivity to Wnts is an emerging hallmark of a subset of cancers, defined in part by mutations regulating the abundance of their receptors. |
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