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ARN14974 Chemical Structure

ARN14974

Data Sheet For research use only. Not for human use.
Cat. No. :BCP20855CAS No. :1644158-57-5Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1644158-57-5 Cat. No. BCP20855
Name ARN14974
Synonyms ARN 14974 ;ARN-14974 ;Acid Ceramidase Inhibitor 17a;
SMILES C1=CC=C(C=C1)CCCCNC(=O)N2C3=C(C=C(C=C3)C4=CC=C(C=C4)F)OC2=O
Chemical Name
Formula C24H21FN2O3 M. Wt 404.44
Purity 98% Storage Store at 4-8°C
Description ARN14974 is a benzoxazolone carboxamide that potently inhibits acid ceramidase (IC50 = 79 nM).1This effect is persistent, as it inhibits acid ceramidase activity in cells for up to 24 hours. ARN14974 is extremely stable in buffers and plasma and shows good pharmacokinetics when administered intravenously or intraperitoneally in mice. It causes a significant reduction in acid ceramidase activity in multiple organs in mice, including brain, liver, heart, lungs, and kidney.
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