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PNU 100592 Chemical Structure

PNU 100592

Data Sheet For research use only. Not for human use.
Cat. No. :BCP12942CAS No. :165800-04-4Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 165800-04-4 Cat. No. BCP12942
Name PNU 100592
Synonyms PNU-100592;PNU100592;Eperezolid;
SMILES
Chemical Name
Formula C18H23FN4O5 M. Wt 394.4
Purity 98% Storage Store at 4-8°C
Description Eperezolid binds specifically to the 50S ribosomal subunit of Escherichia coli. The specific binding of eperezolid is dose dependent and is proportional to the ribosome concentrations. Scatchard analysis of the binding data reveals that the dissociation constant (Kd) is about 20 microM. The binding of eperezolid to the ribosome is competitively inhibited by chloramphenicol and lincomycin. However, unlike chloramphenicol and lincomycin, eperezolid does not inhibit the puromycin reaction, indicating that the oxazolidinones have no effect on peptidyl transferase . eperezolid was found to bind only to the 50S subunit, with similar affinity as to the 70S ribosome, and to have no affinity for the 30S subunit .
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