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PT-2385 Chemical Structure

PT-2385

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP20661CAS No. ：1672665-49-4Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1672665-49-4 Cat. No. BCP20661
Name PT-2385
Synonyms PT 2385;PT2385;
SMILES
Chemical Name
Formula C17H12F3NO4S M. Wt 383.34
Purity 98% Storage Store at 4-8°C
Description PT2385 is an orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. Upon oral administration, HIF-2alpha inhibitor PT2385 allosterically binds to HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and survival.
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H-NMR
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