Zosuquidar 3HCl
Data Sheet
For research use only. Not for human use.
Get Quotation Now Tel: 0086-17754423994 or orders@biochempartner.com
Real-Time Inquiry ×
* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
Inquiry Online
×
* Required Fields.
Please complete the form below and we will contact you shortly.
Bulk Inquiry
×
* Required Fields.
Please complete the form below and we will contact you shortly.
| CAS No. | 167465-36-3 | Cat. No. | BCP02954 |
| Name | Zosuquidar 3HCl | ||
| Synonyms | LY335979;RS 33295-198; Zosuquidar trihydrochloride;LY335979;LY-335979; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C32H31F2N3O2.3HCl | M. Wt | 636.99 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | LY335979 competitively inhibits equilibrium binding of vinblastine to Pgp by blocking azidopine photoaffinity labeling of the Pgp in CEM/VLB100 plasma membranes.LY335979 alone shows the cytotoxicity to drug-sensitive and MDR cell lines with IC50 ranging from 6 μM-16 μM and produces its ability to completely reverse the resistance of the oncolytics (vinblastine, doxorubicin, or etoposide) to the MDR cell lines P388/ADR, MCF7/ADR, 2780AD, or UCLA-P3.003VLB at concentration of 0.1 and 0.5 μM. LY335979 significantly restores drug sensitivity in P-gp-expressing leukemia cell lines including K562/HHT40, K562/HHT90, K562/DOX and HL60/DNR, and enhances the cytotoxicity of anthracyclines (daunorubicin, idarubicin, mitoxantrone) and gemtuzumab ozogamicin (Mylotarg) in primary AML blasts with active P-gp. A latest paper indicates that LY335979 completely inhibits apically directed transport of (Z)-endoxifen in the ABCB1-transduced cells. | ||
In the process of purchasing and using Biochempartner products, you can consult us if you have any problems: orders@biochempartner.com. We will try our best to solve all your doubts.
Recommend Products
More >
Tags:Zosuquidar 3HCl supplier,Zosuquidar 3HCl purchase,Zosuquidar 3HCl manufacturer,Zosuquidar 3HCl distributor,Zosuquidar 3HCl cost,Zosuquidar 3HCl buy,Zosuquidar 3HCl for sale