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CAS No. | 167933-07-5 | Cat. No. | BCP02131 |
Name | Flibanserin | ||
Synonyms | BIMT-17;BIMT 17;BIMT 17; BIMT 17BS; BIMT-17BS; BIMT17BS; EBD6396; EBD 6396; EBD-6396; | ||
SMILES | |||
Chemical Name | |||
Formula | C20H21F3N4O | M. Wt | 390.4 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Flibanserin is a full agonist of the 5-HT1A receptor (Ki = 1 nM) and, with lower affinity, as an antagonist of the 5-HT2A receptor (Ki = 49 nM) and antagonist or very weak partial agonist of the D4 receptor (Ki = 4–24 nM). Despite the much greater affinity of flibanserin for the 5-HT1A receptor, and for reasons that are unknown, flibanserin occupies the 5-HT1A and 5-HT2A receptors in vivo with similar percentages. Flibanserin also has low affinity for the 5-HT2B receptor (Ki = 89.3 nM) and the 5-HT2C receptor (Ki = 88.3 nM), both of which it behaves as an antagonist of. |
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