KO-947
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1695533-89-1 | Cat. No. | BCP25116 |
| Name | KO-947 | ||
| Synonyms | KO947;KO 947; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C21H17N5O | M. Wt | 355.40 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | KO-947 is a potent and selective ERK inhibitor with slow dissociation kinetics. KO-947 showed potent inhibition of ERK signaling pathways and proliferation of tumor cells exhibiting dysregulation of MAPK pathway, including mutations in BRAF, NRAS or KRAS. KO-947 also inhibits MAPK signaling and cell proliferation in preclinical models that are resistant to BRAF and MEK inhibitors. KO-947 induces tumor regressions in BRAF or RAS mutated tumor models as well as in tumor models lacking BRAF/RAS mutations but characterized by other dysregulation of the MAPK pathway. | ||
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