Alvimopan dihydrate
Data Sheet
For research use only. Not for human use.
Get Quotation Now* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
| CAS No. | 170098-38-1 | Cat. No. | BCP10120 |
| Name | Alvimopan dihydrate | ||
| Synonyms | LY 246736 dihydrate;ADL 8-2698 dihydrate; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C25H36N2O6 | M. Wt | 460.56 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | in vitro: The dissociation rate of alvimopan from the micro opioid receptor (t(1/2)=30--44 min) was comparable to that of the long acting partial agonist buprenorphine (t(1/2)=44 min), but was slower than those of the antagonists naloxone (t(1/2)=0.82 min) and N-methylnaltrexone (t(1/2)=0.46 min). in vivo: Alvimopan did not significantly accelerate GI-3 compared with placebo [6 mg: hazard ratio (HR) = 1.20, p = 0.080; 12 mg: HR = 1.24, p = 0.038). However, after adjustment for significant covariates (sex/surgical duration), benefits were significant for both doses (6 mg: HR = 1.24, p = 0.037; 12 mg: HR = 1.26, p = 0.028). Alvimopan also significantly accelerated time to GI-2 (6 mg: HR = 1.37, p = 0.008; 12 mg: HR = 1.33, p = 0.018) and DCO (6 mg: HR = 1.31, p = 0.008; 12 mg: HR = 1.28, p = 0.015) [3]. Alvimopan (1 and 3 mg/kg) significantly reversed this delayed GI transit when administered 45 min prior to surgery. However, the effects of alvimopan were less pronounced when administere | ||
Recommend Products
More >
-
Nalbuphine hydrochloride
Cat. No.：BCP49247
No.：23277-43-2
Product Details -
Bevenopran
Cat. No.：BCP48962
No.：676500-67-7
Product Details -
-
BMS-986122
Cat. No.：BCP46445
No.：313669-88-4
Product Details -
Difelikefalin TFA
Cat. No.：BCP44865
No.：2742623-88-5
Product Details -
-
Difelikefalin HCl
Cat. No.：BCP44189
No.：2413256-25-2
Product Details -
-
Difelikefalin acetate
Cat. No.：BCP42797
No.：1024829-44-4
Product Details -
BMS986188
Cat. No.：BCP37890
No.：1776115-10-6
Product Details -
-
-
EST73502 HCl
Cat. No.：BCP37164
No.：2307458-82-6
Product Details -
AR-M 1000390 hydrochloride
Cat. No.：BCP35047
No.：209808-47-9
Product Details -
LY-2795050
Cat. No.：BCP33958
No.：1346133-08-1
Product Details -
Aticaprant
Cat. No.：BCP32123
No.：1174130-61-0
Product Details -
BTRX-335140
Cat. No.：BCP32121
No.：2244614-14-8
Product Details -
Difelikefalin
Cat. No.：BCP24752
No.：1024828-77-0
Product Details -
-
Tags:Alvimopan dihydrate supplier,Alvimopan dihydrate purchase,Alvimopan dihydrate manufacturer,Alvimopan dihydrate distributor,Alvimopan dihydrate cost,Alvimopan dihydrate buy,Alvimopan dihydrate for sale