Nepicastat HCl
Data Sheet
For research use only. Not for human use.
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| CAS No. | 170151-24-3 | Cat. No. | BCP06517 |
| Name | Nepicastat HCl | ||
| Synonyms | SYN-117;SYN117;RS 25560-197;Nepicastat hydrochloride; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C14H15F2N3S.HCl | M. Wt | 331.81 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | In the artery, left ventricle and cerebral cortex of spontaneously hypertensive rats (SHRs), Nepicastat hydrochloride reduces noradrenaline content, and increases dopamine content and dopamine/noradrenaline ratio in a dose-dependent manner. In addition, Nepicastat hydrochloride also produces the similar effects on noradrenaline, dopamine and dopamine/noradrenaline ratio in tissues and plasma of beagle dogs. In inactin-anesthetized SHRs, Nepicastat hydrochloride (3 mg/kg, i.v.) produces the antihypertensive effects and causes a significant decrease in renal vascular resistance (38%) and an increase in renal blood flow (22%). In dogs with chronic heart failure, low-dose Nepicastat hydrochloride (0.5 mg/kg) prevents left ventricular (LV) dysfunction and remodeling, and combination therapy of Nepicastat hydrochloride and enalapril results in additional improvements in all morphological features. In rat brain, Nepicastat hydrochloride at a dose of 50 mg/kg ( i.p.) leads to the reduction of | ||
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