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AG-1478.hcl Chemical Structure

AG-1478.hcl

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP01312CAS No. ：170449-18-0Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 170449-18-0 Cat. No. BCP01312
Name AG-1478.hcl
Synonyms Tyrphostin AG-1478;AG 1478;AG1478;Tyrphostin AG 1478;
SMILES
Chemical Name
Formula C16H15Cl2N3O2.HCl M. Wt 352.22
Purity 98% Storage Store at 4-8°C
Description AG-1478 preferentially inhibits U87MG cells expressing truncated EGFR with IC50 of 8.7 μM, compared to those expressing endogenous wt EGFR or overexpressing exogenous wt EGFR with IC50 of 34.6 μM and 48.4 μM, respectively, and inhibits the DNA synthesis with IC50 of 4.6 μM, 19.67 μM, and 35.2 μM, respectively. AG-1478 also preferentially inhibits the tyrosine kinase activity and autophosphorylation of the ΔEGFR compared to endogenous or overexpressed exogenous wt EGFR. AG-1478 (0.25 μM) abolishe
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H-NMR LCMS
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