Fisogatinib New
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| CAS No. | 1707289-21-1 | Cat. No. | BCP16535 |
| Name | Fisogatinib | ||
| Synonyms | Blu-554;Blu 554;Blu554; | ||
| SMILES | COC1=CC(=C(C(=C1Cl)C2=CC3=CN=C(N=C3C=C2)NC4COCCC4NC(=O)C=C)Cl)OC | ||
| Chemical Name | |||
| Formula | C24H24Cl2N4O4 | M. Wt | 503.38 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Fisogatinib is an orally bioavailable inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon oral administration, fisogatinib specifically binds to and blocks the binding of the ligand FGF19 to FGFR4. This prevents the activation of FGFR4, inhibits FGFR4-mediated signaling and leads to an inhibition of tumor cell proliferation in FGFR4-overexpressing cells. FGFR4 is a receptor tyrosine kinase and is involved in tumor cell proliferation, differentiation, angiogenesis, and survival. FGF19 is overexpressed by certain tumor cell types. | ||
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