Efaproxiral sodium
Data Sheet
For research use only. Not for human use.
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| CAS No. | 170787-99-2 | Cat. No. | BCP07458 |
| Name | Efaproxiral sodium | ||
| Synonyms | RSR13 sodium; RSR-13 sodium; RSR 13 sodium; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C20H22NNaO4 | M. Wt | 363.38 |
| Purity | 99% | Storage | Store at 4-8°C |
| Description | Efaproxiral sodium is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.Efaproxiral, also known as RSR13, is a synthetic small molecule with radiosensitizing activity. Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. One use for efaproxiral is to increase the efficacy of certain chemotherapy drugs which have reduced efficacy against hypoxic tumours, and can thus be made more effective by increased offloading of oxygen into the tumour tissues. However, no benefit was seen for efaproxiral in phase III clinical trials. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). | ||
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