PD158780

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP07290CAS No. ：171179-06-9Purity：98%

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CAS No.	171179-06-9	Cat. No.	BCP07290
Name	PD158780
Synonyms	PD-158780;PD 158780;
SMILES
Chemical Name
Formula	C14H12BrN5	M. Wt	330.19
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: PD158780 potently inhibited the LPA-stimulated MAP kinase kinase 1/2 (MKK1/2) activation and EGF receptor tyrosine phosphorylation in HeLa cells, while it had no detectable effect on c-Src kinase activity. PD158780 also inhibited LPA-induced MKK1/2 activation and DNA synthesis in NIH 3T3 cells. Furthermore, we compared LPA-stimulated MKK1/2 and MAP kinase activation, transcriptional activity of the c-fos promoter, and DNA synthesis in B82L cells, which lack endogenous EGF receptor, and B82L cells expressing kinase-defective or wild-type human EGF receptor . in vivo: NRG-1beta dramatically increases gamma oscillation power in hippocampal slices from both rats (2062 +/- 496%) and mice (710 +/- 299%). These effects of NRG-1beta are blocked by PD158780, a pan-specific antagonist of ErbB receptors, and are mediated specifically via ErbB4 receptors, because mice harboring a targeted mutation of ErbB4 do not respond to NRG-1 .